Assay

Financial-condition grades for SEC filers

Company Report · as of Oct 9, 2026

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MethodCoverageAbout
Annovis Bio, Inc.ANVS · healthcare
GradeNonecomputable_factors_below_threshold: 3 of 14 inputs computable; 7 are required
Reliability0.83 AUCfailure model, filers with $12.5M to $120M assets; 95% interval 0.79 to 0.86; 201 events, 2020 to 2025
Peer failure rate1.07% a yearItem 1.03 bankruptcies, same asset band, 2012 to 2025
Size band$12.5M to $120M assetstotal assets $21.1M[1]
Standard universeoutsiderevenue above $1M and assets above $10M[1-2]
Warningsdilution, short runway, thin data, degenerate inputsnot computable: distress, fortress balance sheet
Inputs computable3 of 14
Graded fromfilings received through Mar 13, 2026210 days before the rescan; every figure keyed to the SEC receipt date
Last close$1.182026-10-08; market equity $50.3M; iex feed
Price used in gradeNone
Share price, twelve months to the rescansplit-adjusted close; a lollipop at every rescan carries the letter held then; baseline ticks are SEC receipt dates of the inputs; ranges and dragging scroll the full history
$2$4NovDecJanFebMarAprMayJunJulAugSepOct$1.17
ABCDE20132014201520162017201820192020202120222023202420252026

Percentile at every rescan on file, Jan 21, 2012 to Oct 9, 2026; stronger toward the top. Hover for the date.

Open this report as it stood on

Letter setLetterPercentileBand
Jan 21, 2012nonen/a
Mar 21, 2021nonen/aQ1
Mar 21, 2022nonen/aQ2
Apr 21, 2024nonen/aQ1
Mar 21, 2025nonen/aQ2

Each date opens the report as it stood on that rescan.

Business, in the company's words. Opening of Item 1 of the 10-K received Mar 13, 2026; the document on sec.gov.

We are a late-stage clinical drug platform company addressing neurodegeneration, such as Alzheimer’s disease (“AD”) and Parkinson’s disease (“PD”). We are developing our lead product candidate, buntanetap, which is designed to address AD, PD, and potentially other chronic neurodegenerative diseases. Buntanetap is a synthetically produced small molecule, orally administered, brain penetrant compound. In several studies, buntanetap was observed to inhibit the synthesis of neurotoxic proteins — APP/Aβ (“APP”), tau/phospho-tau (“tau”), α-Synuclein (“αSYN”) and TDP43 — that are some of the main causes of neurodegeneration.

Warnings [top]

Dilution. split-adjusted year-over-year share growth is 45.5%[3-4]
Short runway. cash runway is 5.2 months[5]
Thin data. 3 of 14 grade factors are computable; minimum is 7
Degenerate inputs. latest revenue or assets are at or below the $100,000 validity floor[1-2]

7 checks ran; none of them enters the letter. The checks are listed on the warnings screen.

The Fourteen Inputs [top]

Lower percentile is stronger. Source numbers open the SEC filing; a range that spans filings opens the sources table.

InputPercentile, 0 to 100ValueSourcePeer medianPercentilePeersPeriod end
Profitability, sleeve percentile 23.7
Gross profitabilitynot computable32.2%
one or more required annual facts are missing
Return on invested capitalnot computable9.3%
one or more required annual facts are missing
Accruals ratio(18.5%)[1,6-8](6.6%)23.78112025-12-31
Gross margin stability, five yearsnot computable2.8 pts
five annual gross margins are required; found 0
Solvency
Twelve-month failure probabilitynot computable0.07%
latest liabilities, cash plus short-term investments, book equity, and shares are required
Altman Z double-primenot computable(0.31)
latest aligned inputs end 2023-12-31; latest annual assets end 2025-12-31
Net debt to EBITDAnot computable1.82x
one or more required annual facts are missing
Interest coveragenot computable(4.51x)
one or more required annual facts are missing
Current rationot computable2.96x
latest aligned inputs end 2023-12-31; latest annual assets end 2025-12-31
Growth and financing, sleeve percentile 76.4
Revenue growth, three-year compoundnot computable10.0%
current value must be positive and the base must exceed $100,000
Free cash flow growth, three-year compoundnot computable10.9%
four consecutive annual FCF observations are required; found 0
Reinvestment ratenot computable37.1%
one or more required annual facts are missing
Asset growth, three years(16.4%)[1,8-10]2.1%77.87042025-12-31
Net share issuance, one year45.5%[3-4]2.5%75.06342026-03-12

Gross profitability. Revenue less cost of goods sold, over total assets.

Accruals ratio. Net income less operating cash flow, over average assets; lower is stronger.

Gross margin stability, five years. Standard deviation of gross margin; lower is stronger.

Twelve-month failure probability. CHS model; lower is stronger.

Net debt to EBITDA. Lower is stronger.

Net share issuance, one year. Split-adjusted; lower is stronger.

Among 371 Peers [top]

What the Price Implies [top]

Market measures at the 2026-10-08 close. None enters the grade. Percentile among graded peers with the same measure.

MeasureValuePeer medianPercentileReading
Twelve-month price change, skipping the latest month(16.9%)8.0%33hotter than 33 of 100 peers
Distance from 52-week high(77.1%)(31.4%)9closer to its high than 9 of 100 peers
EBIT to enterprise valuenot computable(1.5%)required accounting or market input is missing
Free cash flow yieldnot computable(1.0%)required accounting or market input is missing
Book value to price(0.09)0.287pricier than 93 of 100 peers
Sales to price0.000.310pricier than 100 of 100 peers
Composite equity issuance, five years181.4%20.3%87more equity-funded than 87 of 100 peers
Relative strength against the sector, log excess return(0.40)(0.14)33ahead of 33 of 100 peers

Inputs: market equity $49.8M; EBIT -$29.7M; book equity -$4.3M; sales $0; cash $18.7M[11].

Diagnostics [top]

Diagnostics do not feed the grade.

Piotroski F-score: None of 9, period end 2025-12-31
Return on assets above zero(207.2%)✗ fail[6,8]
Operating cash flow above zero-$25.6M✗ fail[7]
Return on assets improved33.7 pts✓ pass[6,8-9,12]
Operating cash flow exceeds net income$3.2M✓ pass[6-7]
Long-term leverage felln/a[1,8-9]
Current ratio improvedn/a[13-14]
No new shares issued45.5%✗ fail[3-4]
Gross margin improvedn/a
Asset turnover improved0.0 pts✗ fail[2,8-9,15]
Cash, filings, liquidity
Cash and equivalents$18.7M[5]
Operating cash flow, four quarters-$43.3M[5,7,16-19]
Months of runway5.2
Late filings, two years0
NT 10-K or NT 10-Q
Days since last periodic filing56
10-Q received Aug 14, 2026
Median daily dollar volume$1.0M
63 sessions
Days since newest grade input210

Downloads [top]

Sources [top]

Every citation on this page. Filing opens the SEC index page for that submission; viewer opens the SEC interactive data for the same filing; series opens the SEC XBRL API record for that tag and company.

#ConceptXBRL tagValuePeriod endReceivedFormLinks
1assetsus-gaap:Assets$21.1M2025-12-312026-03-1310-Kfiling · viewer · series
2revenueus-gaap:RevenueFromContractWithCustomerExcludingAssessedTax$02025-12-312026-03-1310-Kfiling · viewer · series
3shares outstandingdei:EntityCommonStockSharesOutstanding28,355,2622026-03-122026-03-1310-Kfiling · viewer · series
4shares outstandingdei:EntityCommonStockSharesOutstanding19,486,2312025-03-182025-03-2110-Kfiling · viewer · series
5cashus-gaap:CashAndCashEquivalentsAtCarryingValue$18.7M2026-06-302026-08-1410-Qfiling · viewer · series
6net incomeus-gaap:NetIncomeLoss-$28.9M2025-12-312026-03-1310-Kfiling · viewer · series
7operating cash flowus-gaap:NetCashProvidedByUsedInOperatingActivities-$25.6M2025-12-312026-03-1310-Kfiling · viewer · series
8assetsus-gaap:Assets$13.9M2024-12-312026-03-1310-Kfiling · viewer · series
9assetsus-gaap:Assets$10.2M2023-12-312025-03-2110-Kfiling · viewer · series
10assetsus-gaap:Assets$36.0M2022-12-312024-03-2910-Kfiling · viewer · series
11shares outstandingdei:EntityCommonStockSharesOutstanding42,606,1522026-08-142026-08-1410-Qfiling · viewer · series
12net incomeus-gaap:NetIncomeLoss-$24.6M2024-12-312026-03-1310-Kfiling · viewer · series
13current liabilitiesus-gaap:LiabilitiesCurrent$3.6M2025-12-312026-03-1310-Kfiling · viewer · series
14current liabilitiesus-gaap:LiabilitiesCurrent$3.9M2024-12-312026-03-1310-Kfiling · viewer · series
15revenueus-gaap:RevenueFromContractWithCustomerExcludingAssessedTax$02024-12-312025-03-2110-Kfiling · viewer · series
16operating cash flowus-gaap:NetCashProvidedByUsedInOperatingActivities-$30.9M2026-06-302026-08-1410-Qfiling · viewer · series
17operating cash flowus-gaap:NetCashProvidedByUsedInOperatingActivities-$9.0M2026-03-312026-05-1510-Qfiling · viewer · series
18operating cash flowus-gaap:NetCashProvidedByUsedInOperatingActivities-$16.7M2025-09-302025-11-1210-Qfiling · viewer · series
19operating cash flowus-gaap:NetCashProvidedByUsedInOperatingActivities-$13.2M2025-06-302026-08-1410-Qfiling · viewer · series

Limitations [top]

Peer group. Sector assignment from four-digit SIC codes, hand-tuned and published. The grade under three alternative peer policies is tabled above.

Size. Within a sector the letter tracks size. Among graded filers in the smallest asset band, 72% grade E and 0% grade A; in the largest, 13% grade E and 21% grade A. Universe as of Oct 9, 2026.

Failure model. filings 2012-01-01 to 2019-12-31 fit, filings 2020-01-01 to 2025-12-31 test; status post hoc pending confirmation. pre-registered on 2026 filings once their 12-month outcome windows close; supported if the paired per-quintile gain over the pooled model has a lower bound above 0.05.

Input validity. Revenue or total assets at or below $100,000 sets the degenerate-inputs flag. An input whose denominator is at or below $100,000 is left not computable rather than ranked.

Returns. No input on this page has a post-2015 confidence interval on returns that excludes zero. The grade ranks reported financial condition and is not a return forecast.

Informational and educational only. Not investment advice. SEC and market data may contain errors.

If you have any comments about this page, the methodology and every line of code that produced it are in the public repository. However, due to the limited number of personnel, we are unable to provide a direct response.

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bull: Raphael Schön from Vienna, Austria, CC BY 2.0; bear: U. S. Fish and Wildlife Service - Northeast Region, Public domain; elk: Oregon Department of Fish & Wildlife, Public domain; tortoise: NPS, Public domain; sloth: Charles J. Sharp, CC BY-SA 3.0; fox: Cp9asngf, CC BY-SA 4.0; sector-business_equipment: Sangitiana Fararano, CC BY-SA 2.0; sector-healthcare: User:Squidonius, myself, and User:Beliason (assumed)., CC BY-SA 4.0; sector-manufacturing: unknown, CC BY-SA 2.0; sector-shops: Wilfredor, CC BY-SA 4.0; sector-consumer_nondurables: Nielsoncaetanosalmeron, CC BY 4.0; sector-utilities: Lijovklm, CC BY-SA 4.0; sector-consumer_durables: Stilfehler, CC BY-SA 4.0; sector-chemicals: PEO ACWA, CC BY 2.0; sector-energy: Arne Hückelheim, CC BY-SA 3.0; sector-telecom: Wikideas1, CC0; sector-other: Downtowngal, CC BY-SA 4.0.

Updated Oct 9, 2026