Assay
Financial-condition grades for SEC filers
Company Report · as of Oct 9, 2026
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| Amylyx Pharmaceuticals, Inc.AMLX · healthcare | |
|---|---|
| Grade |  Dfourth fifth of 371 graded peers; percentile 67.6, sampling error 2.5 points; lower is stronger |
| Rank | 251 of 371 |
| Profitability | Dpercentile 71.7 |
| Solvency | Bpercentile 26.2 |
| Growth and financing | Dpercentile 63.5 |
| Reliability | 0.87 AUCfailure model, filers with $120M to $591M assets; 95% interval 0.83 to 0.90; 206 events, 2020 to 2025 |
| Peer failure rate | 1.03% a yearItem 1.03 bankruptcies, same asset band, 2012 to 2025 |
| Size band | $120M to $591M assetstotal assets $332.6M[1] |
| Standard universe | outsiderevenue above $1M and assets above $10M[1-2] |
| Warnings | short runway, degenerate inputsnot computable: fortress balance sheet |
| Inputs computable | 7 of 14 |
| Graded from | filings received through Mar 3, 2026220 days before the rescan; every figure keyed to the SEC receipt date |
| Last close | $27.222026-10-08; market equity $3.0B; iex feed |
| Price used in grade | None |
| Share price, twelve months to the rescansplit-adjusted close; a lollipop at every rescan carries the letter held then; baseline ticks are SEC receipt dates of the inputs; ranges and dragging scroll the full history | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Percentile at every rescan on file, Jan 21, 2012 to Oct 9, 2026; stronger toward the top. Hover for the date. Open this report as it stood on | ||||||||||||||||
Each date opens the report as it stood on that rescan. |
Business, in the company's words. Opening of Item 1 of the 10-K received Mar 3, 2026; the document on sec.gov.
Amylyx Pharmaceuticals, Inc. (also referred to as Amylyx, we, our or us) is a clinical-stage pharmaceutical company with a mission to develop and advance novel therapies for communities with high unmet medical needs. We have preclinical and clinical development programs underway in endocrine conditions and neurodegenerative diseases. We are advancing a pipeline in which we have matched investigational therapies with diseases for which we believe these therapies can make the greatest impact, based on well-defined mechanistic rationales, clear clinical outcomes and biomarkers, and rigorous preclinical data, agnostic of modality. Our current pipeline is represented in the table below.
Warnings [top]
7 checks ran; none of them enters the letter. The checks are listed on the warnings screen.
The Fourteen Inputs [top]
Lower percentile is stronger. Source numbers open the SEC filing; a range that spans filings opens the sources table.
| Input | Percentile, 0 to 100 | Value | Source | Peer median | Percentile | Peers | Period end |
|---|---|---|---|---|---|---|---|
| Profitability, sleeve percentile 71.7 | |||||||
| Gross profitability | 0.0% | [1-2,4] | 32.2% | 95.8 | 372 | 2025-12-31 | |
| Return on invested capital | not computable | 9.3% | |||||
| one or more required annual facts are missing | |||||||
| Accruals ratio | (8.1%) | [1,5-7] | (6.6%) | 47.7 | 811 | 2025-12-31 | |
| Gross margin stability, five years | not computable | 2.8 pts | |||||
| five annual gross margins are required; found 4 | |||||||
| Solvency, sleeve percentile 26.2 | |||||||
| Twelve-month failure probability | 0.10% | 0.07% | 57.5 | 248 | 2026-06-30 | ||
| Altman Z double-prime | 7.18 | [1,8-13] | (0.31) | 13.2 | 756 | 2025-12-31 | |
| Net debt to EBITDA | not computable | 1.82x | |||||
| one or more required annual facts are missing | |||||||
| Interest coverage | not computable | (4.51x) | |||||
| one or more required annual facts are missing | |||||||
| Current ratio | 14.27x | [8-9] | 2.96x | 8.0 | 839 | 2025-12-31 | |
| Growth and financing, sleeve percentile 63.5 | |||||||
| Revenue growth, three-year compound | not computable | 10.0% | |||||
| current value must be positive and the base must exceed $100,000 | |||||||
| Free cash flow growth, three-year compound | not computable | 10.9% | |||||
| current FCF must be positive and base FCF must exceed $100,000 | |||||||
| Reinvestment rate | not computable | 37.1% | |||||
| pretax income must exceed the validity floor and imply a 0%-100% tax rate | |||||||
| Asset growth, three years | (5.3%) | [1,7,14-15] | 2.1% | 62.4 | 704 | 2025-12-31 | |
| Net share issuance, one year | 24.8% | [16-17] | 2.5% | 64.6 | 634 | 2026-02-23 | |
Gross profitability. Revenue less cost of goods sold, over total assets.
Accruals ratio. Net income less operating cash flow, over average assets; lower is stronger.
Gross margin stability, five years. Standard deviation of gross margin; lower is stronger.
Twelve-month failure probability. CHS model; lower is stronger.
Net debt to EBITDA. Lower is stronger.
Net share issuance, one year. Split-adjusted; lower is stronger.
Sleeves are equal-weighted; within a sleeve each computable input carries equal weight. Composite 0.084; sampling error 2.5 percentile points on 371 peers.
Among 371 Peers [top]
Composite score of every graded peer, smoothed. Vertical rules are the letter band edges at the 20th, 40th, 60th and 80th percentiles. Small dots are the six largest peers by market equity.
| Rank | Company | Percentile | Letter | Warnings |
|---|---|---|---|---|
| 246 | Angiodynamics Inc. (ANGO) Angiodynamics Inc. (ANGO) Dfourth fifth; percentile 66.2 Nasdaq · Surgical & Medical Instruments & Apparatus market equity $472.3M; last close $11.22 Warnings: fortress balance sheet; 7 of 14 inputs | 66.2 | D | fortress balance sheet |
| 247 | AIM ImmunoTech Inc. (AIM) AIM ImmunoTech Inc. (AIM) Dfourth fifth; percentile 66.5 NYSE · Biological Products, (No Diagnostic Substances) market equity $5.5M; last close $0.18 Warnings: late filer, degenerate inputs, distress; 8 of 14 inputs | 66.5 | D | late filer, degenerate inputs, distress |
| 248 | Exagen Inc. (XGN) Exagen Inc. (XGN) Dfourth fifth; percentile 66.8 Nasdaq · Services-Medical Laboratories market equity $197.9M; last close $8.15 Warnings: dilution, fortress balance sheet; 8 of 14 inputs | 66.8 | D | dilution, fortress balance sheet |
| 249 | PTC Therapeutics, Inc. (PTCT) PTC Therapeutics, Inc. (PTCT) Dfourth fifth; percentile 67.0 Nasdaq · Pharmaceutical Preparations market equity $5.2B; last close $62.55 No active warnings; 8 of 14 inputs | 67.0 | D | |
| 250 | Cardiff Oncology, Inc. (CRDF) Cardiff Oncology, Inc. (CRDF) Dfourth fifth; percentile 67.3 Nasdaq · Biological Products, (No Diagnostic Substances) market equity $82.5M; last close $1.07 Warnings: short runway, fortress balance sheet; 7 of 14 inputs | 67.3 | D | short runway, fortress balance sheet |
| 251 | Amylyx Pharmaceuticals, Inc. (AMLX) Amylyx Pharmaceuticals, Inc. (AMLX) Dfourth fifth; percentile 67.6 Nasdaq · Pharmaceutical Preparations market equity $3.0B; last close $27.22 Warnings: short runway, degenerate inputs; 7 of 14 inputs | 67.6 | D | short runway, degenerate inputs |
| 252 | U S Physical Therapy Inc. (USPH) U S Physical Therapy Inc. (USPH) Dfourth fifth; percentile 67.8 NYSE · Services-Health Services market equity $1.2B; last close $83.40 No active warnings; 10 of 14 inputs | 67.8 | D | |
| 253 | American Shared Hospital Services (AMS) American Shared Hospital Services (AMS) Dfourth fifth; percentile 68.1 NYSE · Services-Medical Laboratories market equity $8.8M; last close $1.48 Warnings: late filer; 10 of 14 inputs | 68.1 | D | late filer |
| 254 | Orchestra BioMed Holdings, Inc. (OBIO) Orchestra BioMed Holdings, Inc. (OBIO) Dfourth fifth; percentile 68.4 Nasdaq · Surgical & Medical Instruments & Apparatus market equity $344.4M; last close $5.72 Warnings: dilution, short runway, fortress balance sheet; 7 of 14 inputs | 68.4 | D | dilution, short runway, fortress balance sheet |
| 255 | Adaptive Biotechnologies Corp. (ADPT) Adaptive Biotechnologies Corp. (ADPT) Dfourth fifth; percentile 68.6 Nasdaq · Biological Products, (No Diagnostic Substances) market equity $4.2B; last close $26.09 No active warnings; 9 of 14 inputs | 68.6 | D | |
| 256 | Iridex Corp. (IRIX) Iridex Corp. (IRIX) Dfourth fifth; percentile 68.9 Nasdaq · Electromedical & Electrotherapeutic Apparatus market equity $15.8M; last close $0.90 Warnings: fortress balance sheet; 8 of 14 inputs | 68.9 | D | fortress balance sheet |
| Peer policy | Letter | Percentile | Peers |
|---|---|---|---|
| all graded filers, equal sleeves | D | 74.5 | 2204 |
| sector peers, equal sleeves (the grade) | D | 67.6 | 371 |
| same exchange, equal sleeves | D | 72.1 | 1219 |
| sector peers, equal inputs | C | 57.0 | 371 |
Each letter is one fifth of the 371 graded peers, about 74 companies. A boundary letter (A/B, B/C, C/D, D/E) marks a percentile within one sampling error of a band edge.
What the Price Implies [top]
Market measures at the 2026-10-08 close. None enters the grade. Percentile among graded peers with the same measure.
| Measure | Value | Peer median | Percentile | Reading |
|---|---|---|---|---|
| Twelve-month price change, skipping the latest month | 148.3% | 8.0% | 93 | hotter than 93 of 100 peers |
| Distance from 52-week high | (31.4%) | (31.4%) | 49 | closer to its high than 49 of 100 peers |
| EBIT to enterprise value | not computable | (1.5%) | required accounting or market input is missing | |
| Free cash flow yield | (4.1%) | (1.0%) | 42 | pricier than 58 of 100 peers |
| Book value to price | 0.08 | 0.28 | 23 | pricier than 77 of 100 peers |
| Sales to price | 0.00 | 0.31 | 0 | pricier than 100 of 100 peers |
| Composite equity issuance, five years | not computable | 20.3% | a share count from five years earlier is required | |
| Relative strength against the sector, log excess return | 0.70 | (0.14) | 93 | ahead of 93 of 100 peers |
Inputs: market equity $3.0B; EBIT -$153.3M; free cash flow -$123.5M; book equity $239.2M; sales $0; cash $49.3M[18].
Diagnostics [top]
Diagnostics do not feed the grade.
| Piotroski F-score: None of 9, period end 2025-12-31 | ||
|---|---|---|
| Return on assets above zero | (74.7%) | ✗ fail[5,7] |
| Operating cash flow above zero | -$123.3M | ✗ fail[6] |
| Return on assets improved | (16.4 pts) | ✗ fail[5,7,14,19] |
| Operating cash flow exceeds net income | $21.4M | ✓ pass[5-6] |
| Long-term leverage fell | n/a[1,7,14] | |
| Current ratio improved | 759.7 pts | ✓ pass[8-9,20-21] |
| No new shares issued | 24.8% | ✗ fail[16-17] |
| Gross margin improved | n/a[2,4,22-23] | |
| Asset turnover improved | (16.9 pts) | ✗ fail[2,7,14,22] |
| Cash, filings, liquidity | |
|---|---|
| Cash and equivalents | $49.3M[3] |
| Operating cash flow, four quarters | -$126.6M[3,6,24-27] |
| Months of runway | 4.7 |
| Late filings, two years | 0 |
| NT 10-K or NT 10-Q | |
| Days since last periodic filing | 64 |
| 10-Q received Aug 6, 2026 | |
| Median daily dollar volume | $42.8M |
| 63 sessions | |
| Days since newest grade input | 220 |
Downloads [top]
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Sources [top]
Every citation on this page. Filing opens the SEC index page for that submission; viewer opens the SEC interactive data for the same filing; series opens the SEC XBRL API record for that tag and company.
| # | Concept | XBRL tag | Value | Period end | Received | Form | Links |
|---|---|---|---|---|---|---|---|
| 1 | assets | us-gaap:Assets | $332.6M | 2025-12-31 | 2026-03-03 | 10-K | filing · viewer · series |
| 2 | revenue | us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax | $0 | 2025-12-31 | 2026-03-03 | 10-K | filing · viewer · series |
| 3 | cash | us-gaap:CashAndCashEquivalentsAtCarryingValue | $49.3M | 2026-06-30 | 2026-08-06 | 10-Q | filing · viewer · series |
| 4 | cost of revenue | us-gaap:CostOfGoodsAndServicesSold | $0 | 2025-12-31 | 2026-03-03 | 10-K | filing · viewer · series |
| 5 | net income | us-gaap:NetIncomeLoss | -$144.7M | 2025-12-31 | 2026-03-03 | 10-K | filing · viewer · series |
| 6 | operating cash flow | us-gaap:NetCashProvidedByUsedInOperatingActivities | -$123.3M | 2025-12-31 | 2026-03-03 | 10-K | filing · viewer · series |
| 7 | assets | us-gaap:Assets | $193.6M | 2024-12-31 | 2026-03-03 | 10-K | filing · viewer · series |
| 8 | current assets | us-gaap:AssetsCurrent | $323.7M | 2025-12-31 | 2026-03-03 | 10-K | filing · viewer · series |
| 9 | current liabilities | us-gaap:LiabilitiesCurrent | $22.7M | 2025-12-31 | 2026-03-03 | 10-K | filing · viewer · series |
| 10 | retained earnings | us-gaap:RetainedEarningsAccumulatedDeficit | -$751.4M | 2025-12-31 | 2026-03-03 | 10-K | filing · viewer · series |
| 11 | operating income | us-gaap:OperatingIncomeLoss | -$153.3M | 2025-12-31 | 2026-03-03 | 10-K | filing · viewer · series |
| 12 | book equity | us-gaap:StockholdersEquity | $305.3M | 2025-12-31 | 2026-03-03 | 10-K | filing · viewer · series |
| 13 | liabilities | us-gaap:Liabilities | $27.4M | 2025-12-31 | 2026-03-03 | 10-K | filing · viewer · series |
| 14 | assets | us-gaap:Assets | $517.5M | 2023-12-31 | 2025-03-04 | 10-K | filing · viewer · series |
| 15 | assets | us-gaap:Assets | $391.5M | 2022-12-31 | 2024-02-22 | 10-K | filing · viewer · series |
| 16 | shares outstanding | dei:EntityCommonStockSharesOutstanding | 110,536,944 | 2026-02-23 | 2026-03-03 | 10-K | filing · viewer · series |
| 17 | shares outstanding | dei:EntityCommonStockSharesOutstanding | 88,602,468 | 2025-02-28 | 2025-03-04 | 10-K | filing · viewer · series |
| 18 | shares outstanding | dei:EntityCommonStockSharesOutstanding | 111,423,048 | 2026-07-27 | 2026-08-06 | 10-Q | filing · viewer · series |
| 19 | net income | us-gaap:NetIncomeLoss | -$301.7M | 2024-12-31 | 2026-03-03 | 10-K | filing · viewer · series |
| 20 | current assets | us-gaap:AssetsCurrent | $189.4M | 2024-12-31 | 2026-03-03 | 10-K | filing · viewer · series |
| 21 | current liabilities | us-gaap:LiabilitiesCurrent | $28.4M | 2024-12-31 | 2026-03-03 | 10-K | filing · viewer · series |
| 22 | revenue | us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax | $87.4M | 2024-12-31 | 2026-03-03 | 10-K | filing · viewer · series |
| 23 | cost of revenue | us-gaap:CostOfGoodsAndServicesSold | $6.0M | 2024-12-31 | 2026-03-03 | 10-K | filing · viewer · series |
| 24 | operating cash flow | us-gaap:NetCashProvidedByUsedInOperatingActivities | -$68.3M | 2026-06-30 | 2026-08-06 | 10-Q | filing · viewer · series |
| 25 | operating cash flow | us-gaap:NetCashProvidedByUsedInOperatingActivities | -$36.9M | 2026-03-31 | 2026-05-07 | 10-Q | filing · viewer · series |
| 26 | operating cash flow | us-gaap:NetCashProvidedByUsedInOperatingActivities | -$95.4M | 2025-09-30 | 2025-11-06 | 10-Q | filing · viewer · series |
| 27 | operating cash flow | us-gaap:NetCashProvidedByUsedInOperatingActivities | -$65.1M | 2025-06-30 | 2026-08-06 | 10-Q | filing · viewer · series |
Limitations [top]
Grade boundary. Percentile 67.6 is 7.6 points from the nearest band edge; sampling error is 2.5 points.
Peer group. Sector assignment from four-digit SIC codes, hand-tuned and published. The grade under three alternative peer policies is tabled above.
Size. Within a sector the letter tracks size. Among graded filers in the smallest asset band, 72% grade E and 0% grade A; in the largest, 13% grade E and 21% grade A. Universe as of Oct 9, 2026.
Failure model. filings 2012-01-01 to 2019-12-31 fit, filings 2020-01-01 to 2025-12-31 test; status post hoc pending confirmation. pre-registered on 2026 filings once their 12-month outcome windows close; supported if the paired per-quintile gain over the pooled model has a lower bound above 0.05.
Input validity. Revenue or total assets at or below $100,000 sets the degenerate-inputs flag. An input whose denominator is at or below $100,000 is left not computable rather than ranked.
Returns. No input on this page has a post-2015 confidence interval on returns that excludes zero. The grade ranks reported financial condition and is not a return forecast.
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