Assay
Financial-condition grades for SEC filers
Company Report · as of Oct 9, 2026
|
| Protagonist Therapeutics, Inc.PTGX · healthcare | |
|---|---|
| Grade |  Astrongest fifth of 371 graded peers; percentile 0.0, sampling error 2.5 points; lower is stronger |
| Rank | 1 of 371 |
| Profitability | Apercentile 16.3 |
| Solvency | Apercentile 7.6 |
| Growth and financing | Bpercentile 28.2 |
| Reliability | 0.91 AUCfailure model, filers with $591M to $2.67B assets; 95% interval 0.88 to 0.94; 160 events, 2020 to 2025 |
| Peer failure rate | 1.01% a yearItem 1.03 bankruptcies, same asset band, 2012 to 2025 |
| Size band | $591M to $2.67B assetstotal assets $668.2M[1] |
| Standard universe | insiderevenue above $1M and assets above $10M[1-2] |
| Warnings | none active · fortress balance sheet |
| Inputs computable | 7 of 14 |
| Graded from | filings received through Feb 25, 2026226 days before the rescan; every figure keyed to the SEC receipt date |
| Last close | $139.912026-10-08; market equity $9.1B; iex feed |
| Price used in grade | None |
| Share price, twelve months to the rescansplit-adjusted close; a lollipop at every rescan carries the letter held then; baseline ticks are SEC receipt dates of the inputs; ranges and dragging scroll the full history | ||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Percentile at every rescan on file, Jan 21, 2012 to Oct 9, 2026; stronger toward the top. Hover for the date. Open this report as it stood on | ||||||||||||||||||||||||||||
Each date opens the report as it stood on that rescan. |
Business, in the company's words. Opening of Item 1 of the 10-K received Feb 25, 2026; the document on sec.gov.
Protagonist Therapeutics, Inc. (referred to as “Protagonist,” the “Company,” “we,” “our” or “us”) is an integrated discovery and development company with a validated technology platform. Our programs fall into three broad therapeutic areas: (i) inflammation and immunology (“I&I”), (ii) hematology and (iii) metabolic diseases. Our aim is to develop medicines for biologically and commercially validated targets which demonstrate a strong differentiation compared to existing therapies.
Warnings [top]
7 checks ran; none of them enters the letter. The checks are listed on the warnings screen.
The Fourteen Inputs [top]
Lower percentile is stronger. Source numbers open the SEC filing; a range that spans filings opens the sources table.
| Input | Percentile, 0 to 100 | Value | Source | Peer median | Percentile | Peers | Period end |
|---|---|---|---|---|---|---|---|
| Profitability, sleeve percentile 16.3 | |||||||
| Gross profitability | not computable | 32.2% | |||||
| one or more required annual facts are missing | |||||||
| Return on invested capital | not computable | 9.3% | |||||
| a prior annual debt, equity, and cash observation is required | |||||||
| Accruals ratio | (26.6%) | [1,5-7] | (6.6%) | 16.3 | 811 | 2025-12-31 | |
| Gross margin stability, five years | not computable | 2.8 pts | |||||
| five annual gross margins are required; found 0 | |||||||
| Solvency, sleeve percentile 7.6 | |||||||
| Twelve-month failure probability | 0.02% | 0.07% | 6.1 | 248 | 2026-06-30 | ||
| Altman Z double-prime | 13.41 | [1,8-13] | (0.31) | 6.1 | 756 | 2025-12-31 | |
| Net debt to EBITDA | not computable | 1.82x | |||||
| EBITDA must exceed $100,000 | |||||||
| Interest coverage | not computable | (4.51x) | |||||
| latest aligned inputs end 2020-12-31; latest annual assets end 2025-12-31 | |||||||
| Current ratio | 12.71x | [8-9] | 2.96x | 10.5 | 839 | 2025-12-31 | |
| Growth and financing, sleeve percentile 28.2 | |||||||
| Revenue growth, three-year compound | 20.1% | [2,14-16] | 10.0% | 31.4 | 415 | 2025-12-31 | |
| Free cash flow growth, three-year compound | not computable | 10.9% | |||||
| current FCF must be positive and base FCF must exceed $100,000 | |||||||
| Reinvestment rate | not computable | 37.1% | |||||
| pretax income must exceed the validity floor and imply a 0%-100% tax rate | |||||||
| Asset growth, three years | 39.2% | [1,7,17-18] | 2.1% | 11.1 | 704 | 2025-12-31 | |
| Net share issuance, one year | 3.9% | [19-20] | 2.5% | 42.2 | 634 | 2026-02-18 | |
Gross profitability. Revenue less cost of goods sold, over total assets.
Accruals ratio. Net income less operating cash flow, over average assets; lower is stronger.
Gross margin stability, five years. Standard deviation of gross margin; lower is stronger.
Twelve-month failure probability. CHS model; lower is stronger.
Net debt to EBITDA. Lower is stronger.
Net share issuance, one year. Split-adjusted; lower is stronger.
Sleeves are equal-weighted; within a sleeve each computable input carries equal weight. Composite -0.774; sampling error 2.5 percentile points on 371 peers.
Among 371 Peers [top]
Composite score of every graded peer, smoothed. Vertical rules are the letter band edges at the 20th, 40th, 60th and 80th percentiles. Small dots are the six largest peers by market equity.
| Rank | Company | Percentile | Letter | Warnings |
|---|---|---|---|---|
| 1 | Protagonist Therapeutics, Inc. (PTGX) Protagonist Therapeutics, Inc. (PTGX) Astrongest fifth; percentile 0.0 Nasdaq · Pharmaceutical Preparations market equity $9.1B; last close $139.91 Warnings: fortress balance sheet; 7 of 14 inputs | 0.0 | A | fortress balance sheet |
| 2 | Delcath Systems, Inc. (DCTH) Delcath Systems, Inc. (DCTH) Astrongest fifth; percentile 0.3 Nasdaq · Surgical & Medical Instruments & Apparatus market equity $521.9M; last close $15.04 Warnings: fortress balance sheet; 8 of 14 inputs | 0.3 | A | fortress balance sheet |
| 3 | Inspire Medical Systems, Inc. (INSP) Inspire Medical Systems, Inc. (INSP) Astrongest fifth; percentile 0.5 NYSE · Surgical & Medical Instruments & Apparatus market equity $1.9B; last close $66.50 Warnings: fortress balance sheet; 10 of 14 inputs | 0.5 | A | fortress balance sheet |
| 4 | Kiniksa Pharmaceuticals International, plc (KNSA) Kiniksa Pharmaceuticals International, plc (KNSA) Astrongest fifth; percentile 0.8 Nasdaq · Pharmaceutical Preparations last close $78.77 No active warnings; 8 of 14 inputs | 0.8 | A | |
| 5 | Mimedx Group, Inc. (MDXG) Mimedx Group, Inc. (MDXG) Astrongest fifth; percentile 1.1 Nasdaq · Surgical & Medical Instruments & Apparatus market equity $673.4M; last close $4.62 Warnings: fortress balance sheet; 10 of 14 inputs | 1.1 | A | fortress balance sheet |
| 6 | Harmony Biosciences Holdings, Inc. (HRMY) Harmony Biosciences Holdings, Inc. (HRMY) Astrongest fifth; percentile 1.4 Nasdaq · Pharmaceutical Preparations market equity $2.3B; last close $39.60 Warnings: fortress balance sheet; 11 of 14 inputs | 1.4 | A | fortress balance sheet |
| Peer policy | Letter | Percentile | Peers |
|---|---|---|---|
| all graded filers, equal sleeves | A | 0.0 | 2204 |
| sector peers, equal sleeves (the grade) | A | 0.0 | 371 |
| same exchange, equal sleeves | A | 0.0 | 1219 |
| sector peers, equal inputs | A | 0.3 | 371 |
Each letter is one fifth of the 371 graded peers, about 74 companies. A boundary letter (A/B, B/C, C/D, D/E) marks a percentile within one sampling error of a band edge.
What the Price Implies [top]
Market measures at the 2026-10-08 close. None enters the grade. Percentile among graded peers with the same measure.
| Measure | Value | Peer median | Percentile | Reading |
|---|---|---|---|---|
| Twelve-month price change, skipping the latest month | 122.4% | 8.0% | 91 | hotter than 91 of 100 peers |
| Distance from 52-week high | (11.8%) | (31.4%) | 81 | closer to its high than 81 of 100 peers |
| EBIT to enterprise value | (1.8%) | (1.5%) | 49 | pricier than 51 of 100 peers |
| Free cash flow yield | 0.6% | (1.0%) | 57 | pricier than 43 of 100 peers |
| Book value to price | 0.09 | 0.28 | 25 | pricier than 75 of 100 peers |
| Sales to price | 0.01 | 0.31 | 5 | pricier than 95 of 100 peers |
| Composite equity issuance, five years | 39.0% | 20.3% | 63 | more equity-funded than 63 of 100 peers |
| Relative strength against the sector, log excess return | 0.59 | (0.14) | 91 | ahead of 91 of 100 peers |
Inputs: market equity $9.1B; EBIT -$158.1M; free cash flow $56.1M; book equity $841.5M; sales $46.0M; debt $9.8M; cash $420.1M[21].
Diagnostics [top]
Diagnostics do not feed the grade.
| Piotroski F-score: None of 9, period end 2025-12-31 | ||
|---|---|---|
| Return on assets above zero | (17.5%) | ✗ fail[5,7] |
| Operating cash flow above zero | $57.7M | ✓ pass[6] |
| Return on assets improved | (94.4 pts) | ✗ fail[5,7,17,22] |
| Operating cash flow exceeds net income | $187.8M | ✓ pass[5-6] |
| Long-term leverage fell | n/a[1,7,17] | |
| Current ratio improved | 22.8 pts | ✓ pass[8-9,23-24] |
| No new shares issued | 3.9% | ✗ fail[19-20] |
| Gross margin improved | n/a | |
| Asset turnover improved | (115.2 pts) | ✗ fail[2,7,14,17] |
| Cash, filings, liquidity | |
|---|---|
| Cash and equivalents | $420.1M[25] |
| Operating cash flow, four quarters | $131.2M[6,25-29] |
| Months of runway | not finite |
| trailing operating cash flow is nonnegative, so runway is not finite | |
| Late filings, two years | 0 |
| NT 10-K or NT 10-Q | |
| Days since last periodic filing | 65 |
| 10-Q received Aug 5, 2026 | |
| Median daily dollar volume | $78.8M |
| 63 sessions | |
| Days since newest grade input | 226 |
Downloads [top]
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Sources [top]
Every citation on this page. Filing opens the SEC index page for that submission; viewer opens the SEC interactive data for the same filing; series opens the SEC XBRL API record for that tag and company.
| # | Concept | XBRL tag | Value | Period end | Received | Form | Links |
|---|---|---|---|---|---|---|---|
| 1 | assets | us-gaap:Assets | $668.2M | 2025-12-31 | 2026-02-25 | 10-K | filing · viewer · series |
| 2 | revenue | us-gaap:RevenueFromContractWithCustomerIncludingAssessedTax | $46.0M | 2025-12-31 | 2026-02-25 | 10-K | filing · viewer · series |
| 3 | cash | us-gaap:CashAndCashEquivalentsAtCarryingValue | $33.0M | 2019-12-31 | 2022-02-28 | 10-K | filing · viewer · series |
| 4 | total debt | us-gaap:LongTermDebt | $9.8M | 2019-12-31 | 2021-03-10 | 10-K | filing · viewer · series |
| 5 | net income | us-gaap:NetIncomeLoss | -$130.1M | 2025-12-31 | 2026-02-25 | 10-K | filing · viewer · series |
| 6 | operating cash flow | us-gaap:NetCashProvidedByUsedInOperatingActivities | $57.7M | 2025-12-31 | 2026-02-25 | 10-K | filing · viewer · series |
| 7 | assets | us-gaap:Assets | $744.7M | 2024-12-31 | 2026-02-25 | 10-K | filing · viewer · series |
| 8 | current assets | us-gaap:AssetsCurrent | $577.6M | 2025-12-31 | 2026-02-25 | 10-K | filing · viewer · series |
| 9 | current liabilities | us-gaap:LiabilitiesCurrent | $45.4M | 2025-12-31 | 2026-02-25 | 10-K | filing · viewer · series |
| 10 | retained earnings | us-gaap:RetainedEarningsAccumulatedDeficit | -$470.7M | 2025-12-31 | 2026-02-25 | 10-K | filing · viewer · series |
| 11 | operating income | us-gaap:OperatingIncomeLoss | -$158.1M | 2025-12-31 | 2026-02-25 | 10-K | filing · viewer · series |
| 12 | book equity | us-gaap:StockholdersEquity | $614.7M | 2025-12-31 | 2026-02-25 | 10-K | filing · viewer · series |
| 13 | liabilities | us-gaap:Liabilities | $53.5M | 2025-12-31 | 2026-02-25 | 10-K | filing · viewer · series |
| 14 | revenue | us-gaap:RevenueFromContractWithCustomerIncludingAssessedTax | $434.4M | 2024-12-31 | 2026-02-25 | 10-K | filing · viewer · series |
| 15 | revenue | us-gaap:RevenueFromContractWithCustomerIncludingAssessedTax | $60.0M | 2023-12-31 | 2026-02-25 | 10-K | filing · viewer · series |
| 16 | revenue | us-gaap:RevenueFromContractWithCustomerIncludingAssessedTax | $26.6M | 2022-12-31 | 2025-02-21 | 10-K | filing · viewer · series |
| 17 | assets | us-gaap:Assets | $358.0M | 2023-12-31 | 2025-02-21 | 10-K | filing · viewer · series |
| 18 | assets | us-gaap:Assets | $247.9M | 2022-12-31 | 2024-02-27 | 10-K | filing · viewer · series |
| 19 | shares outstanding | dei:EntityCommonStockSharesOutstanding | 63,808,716 | 2026-02-18 | 2026-02-25 | 10-K | filing · viewer · series |
| 20 | shares outstanding | dei:EntityCommonStockSharesOutstanding | 61,384,289 | 2025-02-19 | 2025-02-21 | 10-K | filing · viewer · series |
| 21 | shares outstanding | dei:EntityCommonStockSharesOutstanding | 64,708,285 | 2026-07-31 | 2026-08-05 | 10-Q | filing · viewer · series |
| 22 | net income | us-gaap:NetIncomeLoss | $275.2M | 2024-12-31 | 2026-02-25 | 10-K | filing · viewer · series |
| 23 | current assets | us-gaap:AssetsCurrent | $591.6M | 2024-12-31 | 2026-02-25 | 10-K | filing · viewer · series |
| 24 | current liabilities | us-gaap:LiabilitiesCurrent | $47.4M | 2024-12-31 | 2026-02-25 | 10-K | filing · viewer · series |
| 25 | cash | us-gaap:CashAndCashEquivalentsAtCarryingValue | $420.1M | 2026-06-30 | 2026-08-05 | 10-Q | filing · viewer · series |
| 26 | operating cash flow | us-gaap:NetCashProvidedByUsedInOperatingActivities | $170.1M | 2026-06-30 | 2026-08-05 | 10-Q | filing · viewer · series |
| 27 | operating cash flow | us-gaap:NetCashProvidedByUsedInOperatingActivities | -$48.9M | 2026-03-31 | 2026-05-05 | 10-Q | filing · viewer · series |
| 28 | operating cash flow | us-gaap:NetCashProvidedByUsedInOperatingActivities | $94.6M | 2025-09-30 | 2025-11-06 | 10-Q | filing · viewer · series |
| 29 | operating cash flow | us-gaap:NetCashProvidedByUsedInOperatingActivities | $96.6M | 2025-06-30 | 2026-08-05 | 10-Q | filing · viewer · series |
Limitations [top]
Grade boundary. Percentile 0.0 is 20.0 points from the nearest band edge; sampling error is 2.5 points.
Peer group. Sector assignment from four-digit SIC codes, hand-tuned and published. The grade under three alternative peer policies is tabled above.
Size. Within a sector the letter tracks size. Among graded filers in the smallest asset band, 72% grade E and 0% grade A; in the largest, 13% grade E and 21% grade A. Universe as of Oct 9, 2026.
Failure model. filings 2012-01-01 to 2019-12-31 fit, filings 2020-01-01 to 2025-12-31 test; status post hoc pending confirmation. pre-registered on 2026 filings once their 12-month outcome windows close; supported if the paired per-quintile gain over the pooled model has a lower bound above 0.05.
Input validity. Revenue or total assets at or below $100,000 sets the degenerate-inputs flag. An input whose denominator is at or below $100,000 is left not computable rather than ranked.
Returns. No input on this page has a post-2015 confidence interval on returns that excludes zero. The grade ranks reported financial condition and is not a return forecast.
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